秀丽隐杆线虫和果蝇中的前后极性——相似与差异
Anterior-posterior polarity in C. elegans and Drosophila--PARallels and differences.
作者信息
Pellettieri Jason, Seydoux Geraldine
机构信息
Department of Molecular Biology and Genetics, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
出版信息
Science. 2002 Dec 6;298(5600):1946-50. doi: 10.1126/science.1072162.
The eggs of Caenorhabditis elegans and Drosophila bear little similarity to each other, yet both depend on the par genes for control of anterior-posterior polarity. Here we explore possible common roles for the par genes (pars) in converting transient asymmetries into stably polarized axes. Although clear mechanistic parallels remain to be established, par-dependent regulation of microtubule dynamics and protein stability emerge as common themes.
秀丽隐杆线虫和果蝇的卵彼此之间几乎没有相似之处，但两者都依赖于par基因来控制前后极性。在这里，我们探讨了par基因（pars）在将短暂的不对称性转化为稳定极化轴方面可能的共同作用。尽管仍有待建立明确的机制相似性，但微管动力学和蛋白质稳定性的par依赖性调节已成为共同主题。
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