[海洛因依赖与儿茶酚-O-甲基转移酶基因-287A/G多态性的关联研究]
[Association study of heroin-dependence and -287 A/G polymorphism of catechol-O-methyltransferase gene].
作者信息
Cao Liping, Li Tao, Xu Ke, Liu Xiehe
机构信息
Institute of Mental Health, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P. R. China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002 Dec;19(6):499-501.
OBJECTIVE
To detect the relationship between heroin-dependence and -287 A/G polymorphism of catechol-O-methyltransferase(COMT) gene.
METHODS
Genotype and allele frequencies of -287 A/G polymorphism of COMT gene were examined in 268 heroin-dependent subjects and 177 normal controls.
RESULTS
Weak but significant difference in genotype of -287 A/G polymorphism of COMT gene was observed between heroin-dependent subjects and controls (chi(2)=7.41, P=0.025), and genotype AA was higher in the former. The frequency of allele A of -287 A/G polymorphism of COMT gene was also significantly higher in heroin-dependent subjects than in the controls (chi(2)=5.69, P=0.017).
CONCLUSION
The results suggested that liability to heroin-dependence was associated with -287 A/G polymorphism of COMT gene.
目的
检测海洛因依赖与儿茶酚-O-甲基转移酶（COMT）基因-287A/G多态性之间的关系。
方法
检测268例海洛因依赖者和177例正常对照者COMT基因-287A/G多态性的基因型及等位基因频率。
结果
海洛因依赖者与对照者COMT基因-287A/G多态性基因型存在微弱但显著的差异（χ²=7.41，P=0.025），前者AA基因型比例更高。海洛因依赖者COMT基因-287A/G多态性的等位基因A频率也显著高于对照者（χ²=5.69，P=0.017）。
结论
结果提示海洛因依赖易感性与COMT基因-287A/G多态性有关。
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