通过稳定的二甲醚 - 聚（氟化氢）（DMEPHF）络合物对与 Merrifield 树脂结合的肽进行脱保护和裂解。一种用于肽化学的新型便捷试剂。

Deprotection and cleavage of peptides bound to Merrifield resin by stable dimethyl ether-poly(hydrogen fluoride) (DMEPHF) complex. a new and convenient reagent for peptide chemistry.

作者信息

Török Béla, Bucsi Imre, Prakash G K Surya, Olah George A

机构信息

Loker Hydrocarbon Research Institute, Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661, USA.

出版信息

Chem Commun (Camb). 2002 Dec 7(23):2882-3. doi: 10.1039/b206168f.

DOI:10.1039/b206168f

PMID:12478794

Abstract

The newly developed stable DMEPHF (1/15) complex was found to be a highly effective reagent for the cleavage of peptides from Merrifield resins; ease of handling and its simple, complete removal from the reaction mixture make the reagent system a very useful HF equivalent for applications in solid-phase peptide synthesis.

摘要

新开发的稳定的DMEPHF(1/15)复合物被发现是一种从Merrifield树脂上裂解肽的高效试剂；易于操作且能简单、完全地从反应混合物中除去，使得该试剂体系成为在固相肽合成应用中非常有用的等效于氢氟酸的试剂。