噬菌体介导的sopE1基因水平转移增加了肠炎沙门氏菌鼠伤寒血清型对犊牛的肠道致病性。

Phage mediated horizontal transfer of the sopE1 gene increases enteropathogenicity of Salmonella enterica serotype Typhimurium for calves.

作者信息

Zhang Shuping, Santos Renato L, Tsolis Renée M, Mirold Susanne, Hardt Wolf-Dietrich, Adams L Garry, Bäumler Andreas J

机构信息

Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4467, USA.

出版信息

FEMS Microbiol Lett. 2002 Dec 17;217(2):243-7. doi: 10.1111/j.1574-6968.2002.tb11482.x.

DOI:10.1111/j.1574-6968.2002.tb11482.x

PMID:12480111

Abstract

Epidemiological evidence shows that the sopE1 gene is associated with Salmonella Typhimurium phage types causing epidemics in cattle. In this study we demonstrate that horizontal transfer of the sopE1 gene by lysogenic conversion with the SopEphi increased enteropathogenicity of S. Typhimurium in the bovine ligated ileal loop model. These data support the hypothesis that phage mediated horizontal transfer of the sopE1 gene contributes to the emergence of epidemic cattle-associated S. Typhimurium clones.

摘要

流行病学证据表明，sopE1基因与引起牛群疫情的鼠伤寒沙门氏菌噬菌体类型有关。在本研究中，我们证明了通过SopEphi溶原性转化进行的sopE1基因水平转移增加了鼠伤寒沙门氏菌在牛结扎回肠袢模型中的肠道致病性。这些数据支持了以下假设：噬菌体介导的sopE1基因水平转移促成了与牛相关的鼠伤寒沙门氏菌流行克隆的出现。