NMDA receptor subunit expression following early postnatal exposure to ethanol.

作者信息

Nixon Kimberly, Hughes Peter D, Amsel Abram, Leslie Steven W

机构信息

Department of Psychology, Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX 78712, USA.

出版信息

Brain Res Dev Brain Res. 2002 Dec 15;139(2):295-9. doi: 10.1016/s0165-3806(02)00515-1.

DOI:10.1016/s0165-3806(02)00515-1

PMID:12480144

Abstract

Changes in NMDA receptor function following early postnatal exposure to ethanol may be related to the expression of NMDA receptor subunits. Following early postnatal exposure to ethanol, the expression of NMDA receptor subunits was examined. In cortex from ethanol-exposed rat pups at postnatal day 21, NR2A was significantly increased. There was no change in NR2B, thus suggesting that ethanol exposure during the third-trimester equivalent produces distinct effects on the NMDA receptor.

摘要