甲状旁腺激素作为一种治疗药物。

Parathyroid hormone as a therapeutic agent.

作者信息

Mitlak Bruce H

机构信息

Medical Advisor, Eli Lilly and Company Lilly Corporate Center, Indianapolis, IN 46285, USA.

出版信息

Curr Opin Pharmacol. 2002 Dec;2(6):694-9. doi: 10.1016/s1471-4892(02)00208-4.

DOI:10.1016/s1471-4892(02)00208-4

PMID:12482733

Abstract

Recent advances in the use of parathyroid hormone as a therapeutic agent include a controlled trial that assessed vertebral and non-vertebral fracture risk reduction in women, trials in men, and assessment of treatment on cortical and trabecular bone structure. The occurrence of osteosarcoma in long-term toxicology studies in rats is briefly reviewed.

摘要

甲状旁腺激素作为一种治疗药物的最新进展包括一项评估女性椎体和非椎体骨折风险降低情况的对照试验、针对男性的试验以及对皮质骨和小梁骨结构治疗效果的评估。本文简要回顾了大鼠长期毒理学研究中骨肉瘤的发生情况。