[The research the relationship between N-acetyltransferase 1 gene polymorphisms and genetic susceptibility to sporadic colorectal adenocarcinoma].

OBJECTIVE

In this study, we analyzed the association genetic polymorphisms of N-acetyltransferase 1 (NAT1) with genetic susceptibility to sporadic colorectal adenocarcinoma (SCRAC).

METHODS

All subjects are unrelated Han people in Hubei province of China. Using multiple PCR and PCR-RFLP, we studied the genotypes and genetic polymorphisms of the NAT1 gene of 101 healthy controls and 104 SCRAC patients.

RESULTS

(1) The frequency of NAT1 * 10 was significantly higher among the SCRAC when compared with the controls (P < 0.05, OR = 1.91, 95% CI = 1.1 - 3.4), and among the elder SCRAC when compared to the controls (P < 0.01, OR = 2.91, 95% CI = 1.48 - 5.90), (2) The frequency of NAT1 * 10 relative to SCRAC tumor location as follow: proximal SCRAC (44.4%), distal SCRAC (41.6%), all the difference were not statistically significant relative to the controls; The frequency of NAT1 * 10 genotype was significantly higher in stage II cases (P < 0.05, OR = 2.48, 95% CI = 1.18 - 5.20) and stage III and IV cases (P < 0.05, OR = 3.04, 95% CI = 1.28 - 7.20) when compared with the controls.

CONCLUSIONS

NAT1 * 10 has increased risk of SCRAC and significantly related to the later stage tumors, is not significantly related to the tumor location, whether the elder individuals with NAT1 * 10 have increased risk of SCRAC needs further study.