Burstyn Igor, Boffetta Paolo, Kauppinen Timo, Heikkilä Pirjo, Svane Ole, Partanen Timo, Stücker Isabelle, Frentzel-Beyme Rainer, Ahrens Wolfgang, Merzenich Hiltrud, Heederik Dick, Hooiveld Mariette, Brunekreef Bert, Langård Sverre, Randem Britt G, Järvholm Bengt, Bergdahl Ingvar A, Shaham Judith, Ferro Gilles, Kromhout Hans
Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Am J Ind Med. 2003 Jan;43(1):40-8. doi: 10.1002/ajim.10168.
We compared performance of different exposure assessment approaches in a cohort study of cancer risk among European asphalt workers.
Three bitumen fume exposure indices (duration of exposure (years), average exposure (mg/m3) and cumulative exposure (mg/m3*years)) and two latency models (with and without a 15 year lag) were considered for an association between lung cancer mortality and bitumen fume.
There was no association between lung cancer risk and either duration or cumulative exposure. However, there was the suggestion of an increase in lung cancer risk accompanying rise in average exposure. Only models with average bitumen fume exposure (with or without lag) improved model fit, albeit to the same extent.
Constructing quantitative indices of exposure intensity was justified because they produced the greatest improvement in fit of models that explored possible relationship between bitumen fume exposure and lung cancer risk. The identified associations require further investigation.
在一项欧洲沥青工人癌症风险队列研究中，我们比较了不同暴露评估方法的性能。
考虑了三个沥青烟暴露指数（暴露持续时间（年）、平均暴露量（毫克/立方米）和累积暴露量（毫克/立方米·年））以及两个潜伏期模型（有和没有15年的滞后），以研究肺癌死亡率与沥青烟之间的关联。
肺癌风险与暴露持续时间或累积暴露量之间均无关联。然而，有迹象表明肺癌风险随着平均暴露量的增加而增加。只有包含平均沥青烟暴露量的模型（有或没有滞后）改善了模型拟合，尽管改善程度相同。
构建暴露强度的定量指标是合理的，因为它们在探索沥青烟暴露与肺癌风险之间可能关系的模型拟合方面有最大程度的改善。所确定的关联需要进一步研究。
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