Mandelkow Eckhard, Mandelkow Eva-Maria
Max-Planck-Unit for Structural Molecular Biology, Hamburg, Germany.
Trends Cell Biol. 2002 Dec;12(12):585-91. doi: 10.1016/s0962-8924(02)02400-5.
Kinesins are motor proteins that move cargoes such as vesicles, organelles and chromosomes along microtubules. They are best known for their role in axonal transport and in mitosis. There is a diverse family of kinesins, members of which differ in composition and functions. Roles of kinesins in diseases typically involve defective transport of cell components, transport of pathogens, or cell division.
驱动蛋白是一类能沿着微管移动囊泡、细胞器和染色体等货物的运动蛋白。它们因在轴突运输和有丝分裂中的作用而最为人所知。驱动蛋白家族种类繁多,其成员在组成和功能上存在差异。驱动蛋白在疾病中的作用通常涉及细胞成分运输缺陷、病原体运输或细胞分裂。