Withers Stephen G, Wakarchuk Warren W, Strynadka Natalie C J
Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, Canada BC V6T 1Z1.
Chem Biol. 2002 Dec;9(12):1270-3. doi: 10.1016/s1074-5521(02)00291-0.
OtsA is required for the biosynthesis of trehalose, a nonreducing disaccharide that is important for bacterial survival and stress responses. In this issue of Chemistry & Biology, the structure of OtsA is uncovered and reveals an unexpected relationship between the enzyme's structure and function.