Philipson Kenneth D, Nicoll Debora A, Ottolia Michela, Quednau Beate D, Reuter Hannes, John Scott, Qiu Zhiyong
Department of Physiology and Cardiovascular Research Laboratory, UCLA School of Medicine, Los Angeles, California 90095, USA.
Ann N Y Acad Sci. 2002 Nov;976:1-10. doi: 10.1111/j.1749-6632.2002.tb04708.x.
An overview of the molecular physiology of the Na(+)/Ca(2+) exchanger is presented. This includes information on the variety of exchangers that have been described and their regulatory properties. Molecular insight is most detailed for the cardiac Na(+)/Ca(2+) exchanger (NCX1). Parts of the NCS1 molecule involved in regulation and ion transport have been elucidated, and initial information on the topology and structure is available.
本文概述了钠/钙交换体的分子生理学。这包括已描述的各种交换体及其调节特性的信息。关于心脏钠/钙交换体(NCX1)的分子见解最为详细。参与调节和离子转运的NCS1分子部分已得到阐明,并且有关于其拓扑结构和结构的初步信息。