脯氨酸78对于1型人类免疫缺陷病毒Nef下调I类人类白细胞抗原至关重要。
Proline 78 is crucial for human immunodeficiency virus type 1 Nef to down-regulate class I human leukocyte antigen.
作者信息
Yamada Takeshi, Kaji Naotoshi, Odawara Takashi, Chiba Joe, Iwamoto Aikichi, Kitamura Yoshihiro
机构信息
Division of Infectious Diseases, Advanced Clinical Research Center, The University of Tokyo, Japan.
出版信息
J Virol. 2003 Jan;77(2):1589-94. doi: 10.1128/jvi.77.2.1589-1594.2003.
Abstract
Human immunodeficiency virus type 1 Nef down-regulates human leukocyte antigen class I (HLA-I) in T lymphocytes, and the down-regulation involves the Nef proline-rich domain (PRD) containing four prolines at positions 69, 72, 75, and 78. We used a Sendai virus vector with nef and examined regulation by Nef of HLA-I and CD4 in suspension cultures of cells such as T lymphocytes. Analyses of a series of PRD substitution mutants indicated that, because the substitution of Pro78 with Ala abolished down-regulation of HLA-I but not of CD4, Pro78 is important for HLA-I down-regulation in T lymphocytes.
摘要
1型人类免疫缺陷病毒Nef可下调T淋巴细胞中的人类白细胞抗原I类分子（HLA-I），这种下调涉及富含脯氨酸结构域（PRD），该结构域在第69、72、75和78位含有四个脯氨酸。我们使用携带nef的仙台病毒载体，并在T淋巴细胞等细胞的悬浮培养物中检测Nef对HLA-I和CD4的调控。一系列PRD替代突变体的分析表明，由于将第78位的脯氨酸替换为丙氨酸消除了HLA-I的下调，但未消除CD4的下调，因此第78位脯氨酸对T淋巴细胞中HLA-I的下调很重要。
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