临床不动杆菌属菌株的特征

Characteristics of clinical Acinetobacter spp. strains.

作者信息

Hostacká A, Klokocníková L

机构信息

Institute of Preventive and Clinical Medicine, 833 01 Bratislava, Slovakia.

出版信息

Folia Microbiol (Praha). 2002;47(5):579-82. doi: 10.1007/BF02818801.

DOI:10.1007/BF02818801

PMID:12503407

Abstract

Resistance to 13 antimicrobial agents, resistance to the bactericidal activity of human serum, hydrophobic properties, lipolytic activity and production of histamine were determined in a total of 50 clinical Acinetobacter spp. strains (A. baumannii, A. lwoffii, A. calcoaceticus, A. haemolyticus). None of the tested isolates showed resistance to meropenem and none of A. lwoffii, A. calcoaceticus and A. haemolyticus strains were resistant to amikacin. Forty-six strains (92%) manifested resistance to ampicillin, 90% to cefuroxime, 68% to ciprofloxacin, 58% to piperacillin, gentamicin and cotrimaxazole, 50% to cefotaxime, 44% to amikacin, 42% to ceftazidime, 38% to piperacillin/tazobactam, 24% to netilmicin and 16% to ampicillin/sulbactam. In particular, A. baumannii and A. calcoaceticus strains showed considerable antibiotic resistance. Thirty-one isolates (62%) showed serum resistance; intermediate sensitivity was found in 19 isolates (38%). The majority of the strains (72%) demonstrated a strongly hydrophobic character; 16% of isolates exhibited moderate hydrophobic properties. All strains showed lipolytic activity; production of histamine was detected in 14 of 43 strains examined.

摘要

对50株临床不动杆菌属菌株（鲍曼不动杆菌、洛菲不动杆菌、醋酸钙不动杆菌、溶血不动杆菌）测定了对13种抗菌药物的耐药性、对人血清杀菌活性的耐药性、疏水性、脂解活性和组胺产生情况。所有测试菌株均未显示对美罗培南耐药，洛菲不动杆菌、醋酸钙不动杆菌和溶血不动杆菌菌株均未对阿米卡星耐药。46株（92%）对氨苄西林耐药，90%对头孢呋辛耐药，68%对环丙沙星耐药，58%对哌拉西林、庆大霉素和复方新诺明耐药，50%对头孢噻肟耐药，44%对阿米卡星耐药，42%对头孢他啶耐药，38%对哌拉西林/他唑巴坦耐药，24%对奈替米星耐药，16%对氨苄西林/舒巴坦耐药。特别是，鲍曼不动杆菌和醋酸钙不动杆菌菌株显示出相当高的抗生素耐药性。31株（62%）显示血清耐药；19株（38%）发现为中度敏感。大多数菌株（72%）表现出强疏水性；16%的分离株表现出中度疏水性。所有菌株均显示脂解活性；在所检测的43株菌株中，有14株检测到组胺产生。