Huang Deliang, Yang Weiyan, Zhou Dingbiao, Han Dongyi, Jiang Sichang
Department of Otolaryngology, General Hospital of Chinese People's Liberation Army, Beijing 100853, China.
Zhonghua Yi Xue Za Zhi. 2002 Oct 25;82(20):1381-4.
To investigate the clinical features, diagnosis, and treatment of glomus jugulare tumor.
The data of 37 patients of glomus jugulare tumor diagnosed by digital subtraction angiography (DSA) and/or operation and pathology, 14 males (37.8%) and 23 females (62.2%), with an average age of 37.2 (3.5 approximately 66 years) and an average course of 4.3 years (1 month - 19 years), were analyzed.
The tumor was located in the left ear in 19 cases, in the right ear in 17 cases, and in both ears in 1 case, totally 38 ears. The tumor was chromaffin in one case with hypertension. One case was complicated by ipsilateral carotid body tumor, and 2 cases were complicated by ipsilateral cholesteatoma. Thirty cases (81.1%) presented pulsatile tinnitus and hearing loss as the main symptoms. Thirteen cases (35.1%) were diagnosed as glomus jugulare tumor at the first visit, and 24 cases (64.9%) were diagnosed as other diseases with an average misdiagnosis period of 4.4 years. Eighteen tumors originated from typanum and 28 tumors from glomus jugulare. According the Fisch classification 1981, the tumors in 11 ears were type A, in 7 ears were type B, in 7 ears type C, in 5 ears type D1, and in 8 ears type D2. All cases, except the one with bilateral lesions, underwent operation. The tumor was completely resected in 30 cases. Postoperatively, facial paralysis was seen in 6 cases, dizziness, hoarseness, and subauricular necrosis was seen in one case respectively. Of the 25 patients followed up with a mean follow-up time of 5.2 years (1.1 - 16.1 years), 3 died of lung cancer, neuroblastoma, or extensive involvement of glomus jugulare tumor respectively, 19 survived without tumor, and 3 survived with the tumor.
Glomus jugulare tumor is likely to involve surrounding important tissues, and to be misdiagnosed. Early surgical removal of the lesion is important.
探讨颈静脉球瘤的临床特征、诊断及治疗方法。
分析37例经数字减影血管造影(DSA)和/或手术及病理确诊的颈静脉球瘤患者资料,其中男性14例(37.8%),女性23例(62.2%),平均年龄37.2岁(3.5至66岁),平均病程4.3年(1个月至19年)。
肿瘤位于左耳19例,右耳17例,双耳1例,共38耳。1例肿瘤为嗜铬细胞瘤并伴有高血压。1例合并同侧颈动脉体瘤,2例合并同侧胆脂瘤。30例(81.1%)以搏动性耳鸣和听力下降为主要症状。13例(35.1%)初诊时被诊断为颈静脉球瘤,24例(64.9%)被误诊为其他疾病,平均误诊时间为4.4年。18个肿瘤起源于鼓室,28个肿瘤起源于颈静脉球。根据1981年Fisch分类,11耳肿瘤为A型,7耳为B型,7耳为C型,5耳为D1型,8耳为D2型。除1例双侧病变患者外,所有患者均接受手术。30例肿瘤完全切除。术后,6例出现面瘫,1例分别出现头晕、声音嘶哑和耳下坏死。25例患者接受随访,平均随访时间5.2年(1.1至16.1年),3例分别死于肺癌、神经母细胞瘤或颈静脉球瘤广泛侵犯,19例无瘤存活,3例带瘤存活。
颈静脉球瘤易累及周围重要组织,且易被误诊。早期手术切除病变很重要。