Sawelson H, Goldberg R E, Annesley W H, Tomer T L
Arch Ophthalmol. 1976 Feb;94(2):221-4. doi: 10.1001/archopht.1976.03910030101004.
The fundus photographs of 308 patients with presumed ocular histoplasmosis syndrome (POHS) were examined. Bilateral macular involvement was found in 20% of the cases. The incidence of maculopathy, peripapillary lesions, and peripheral "punched-out" lesions in one fundus and only peeipapillary changes in the fellow eye was 12%. The incidence of these features in one fundus and clinically inactive, atrophic scars in the posterior pole of the fellow eye was 23%. Twenty-five patients with atrophic lesions in the macular area of the fellow eye were followed for an average of 24 months. Six patients (24%) demonstrated activation of eight previously documented atrophic lesions resulting in macular involvement. One patient also demonstrated activation from a pre-existing juxtapapillary lesion. None of the remaining 18 patients exhibited any evidence of serous or hemorrhagic retinal sequelae in the fellow eye.
对308例疑似眼组织胞浆菌病综合征（POHS）患者的眼底照片进行了检查。20%的病例发现双侧黄斑受累。一只眼出现黄斑病变、视盘周围病变和周边“打孔样”病变，而另一只眼仅出现视盘周围改变的发生率为12%。一只眼出现这些特征，而另一只眼后极部有临床静止的萎缩性瘢痕的发生率为23%。对25例另一只眼黄斑区有萎缩性病变的患者平均随访24个月。6例患者（24%）出现8处先前记录的萎缩性病变活化，导致黄斑受累。1例患者还出现了先前存在的视盘旁病变活化。其余18例患者中，没有1例在另一只眼中表现出浆液性或出血性视网膜后遗症的任何证据。
