在对Ph阳性慢性粒细胞白血病进行干扰素治疗后发生的Ph阴性急性淋巴细胞白血病。

Ph-negative acute lymphocytic leukemia occurring after interferon therapy for Ph-positive chronic myelocytic leukemia.

作者信息

Zhang Xinwei, Ji Linxiang, Liu Shihe, Wang Jianxiang

机构信息

Department of Clinical Hematology, Institute of Hematology, Blood Diseases Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, PR China.

出版信息

Leuk Res. 2003 Apr;27(4):367-9. doi: 10.1016/s0145-2126(02)00175-3.

DOI:10.1016/s0145-2126(02)00175-3

PMID:12531230

Abstract

We report a unique case of chronic myelocytic leukemia (CML) with the Philadelphia (Ph) chromosome. The patient obtained cytogenetic complete remission (CR) after treatment with interferon (IFN). When he transformed to acute lymphocytic leukemia (ALL), cytogenetic analysis showed that the karyotype was normal and fluorescence in situ hybridization (FISH) indicated that blast cells were Ph-negative. Immunophenotyping showed that the cells were CD34-positive and CD38-negative. Blast cells in his final stage were BCR/ABL rearrangement negative by reverse transcription polymerase chain reaction (RT-PCR).

摘要

我们报告了一例独特的伴有费城（Ph）染色体的慢性粒细胞白血病（CML）病例。该患者在接受干扰素（IFN）治疗后获得了细胞遗传学完全缓解（CR）。当他转变为急性淋巴细胞白血病（ALL）时，细胞遗传学分析显示核型正常，荧光原位杂交（FISH）表明原始细胞为Ph阴性。免疫表型分析显示细胞为CD34阳性和CD38阴性。其终末期原始细胞经逆转录聚合酶链反应（RT-PCR）检测BCR/ABL重排为阴性。