Ohta Kentaro, Iwai Masanori, Sato Keiko, Omori Nobuhiko, Nagano Isao, Shoji Mikio, Abe Koji
Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
Neurosci Lett. 2003 Jan 2;335(3):159-62. doi: 10.1016/s0304-3940(02)01177-1.
To investigate the effect of aging on the oligodendrocyte progenitor cells (OPCs) after cerebral ischemia, neuron-glia antigen 2 (NG2) chondroitin sulfate proteoglycan was examined at 1, 3 and 7 days after 90 min of transient middle cerebral artery occlusion in young and aged brains. The number of NG2 positive cells increased in the ischemic penumbra at 3 and 7 days after reperfusion, while those decreased in the ischemic core. At 7 days, the number of NG2 positive cells was significantly greater in the young than the aged brains, and the processes of NG2 positive cells enlarged and were highly branched in the young than the aged brains. These results suggest that the young brain showed a higher potential of proliferation and process branching of OPCs than the aged brains.
为研究衰老对脑缺血后少突胶质前体细胞（OPCs）的影响，在年轻和老龄大脑中，于大脑中动脉短暂闭塞90分钟后的第1、3和7天检测神经胶质抗原2（NG2）硫酸软骨素蛋白聚糖。再灌注后第3天和第7天，缺血半暗带中NG2阳性细胞数量增加，而缺血核心区的NG2阳性细胞数量减少。在第7天，年轻大脑中NG2阳性细胞数量显著多于老龄大脑，且与老龄大脑相比，年轻大脑中NG2阳性细胞的突起更粗大且分支更多。这些结果表明，与老龄大脑相比，年轻大脑中OPCs的增殖和突起分支潜力更高。
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