根据世界卫生组织分类标准，氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）在淋巴瘤中的应用价值。
Utility of FDG-PET scanning in lymphoma by WHO classification.
作者信息
Elstrom Rebecca, Guan Liang, Baker Gary, Nakhoda Khozaim, Vergilio Jo-Anne, Zhuang Hongming, Pitsilos Stephanie, Bagg Adam, Downs Lisa, Mehrotra Amit, Kim Scott, Alavi Abass, Schuster Stephen J
机构信息
Abramson Family Cancer Research Institute of the University of Pennsylvania, Philadelphia, USA.
出版信息
Blood. 2003 May 15;101(10):3875-6. doi: 10.1182/blood-2002-09-2778. Epub 2003 Jan 16.
We retrospectively evaluated (18)fluoro-2-deoxyglucose positron emission tomography (FDG-PET) scans in 172 patients with lymphoma and correlated results with pathologic diagnosis using the World Health Organization (WHO) classification system. In total, FDG-PET detected disease in at least one site in 161 patients (94%) and failed to detect disease in 11 patients (6%). The most frequent lymphoma diagnoses were diffuse large B-cell lymphoma (LBCL; n = 51), Hodgkin lymphoma (HL; n = 47), follicular lymphoma (FL; n = 42), marginal zone lymphoma (MZL; n = 12), mantle cell lymphoma (MCL; n = 7), and peripheral T-cell lymphoma (PTCL; n = 5). FDG-PET detected disease in 100% of patients with LBCL and MCL and in 98% of patients with HL and FL. In contrast, FDG-PET detected disease in only 67% of MZL and 40% of PTCL. Comparison with bone marrow biopsies showed that FDG-PET was not reliable for detection of bone marrow involvement in any lymphoma subtype.
我们回顾性评估了172例淋巴瘤患者的（18）氟-2-脱氧葡萄糖正电子发射断层扫描（FDG-PET），并使用世界卫生组织（WHO）分类系统将结果与病理诊断进行关联。总体而言，FDG-PET在161例患者（94%）的至少一个部位检测到疾病，在11例患者（6%）中未检测到疾病。最常见的淋巴瘤诊断为弥漫性大B细胞淋巴瘤（LBCL；n = 51）、霍奇金淋巴瘤（HL；n = 47）、滤泡性淋巴瘤（FL；n = 42）、边缘区淋巴瘤（MZL；n = 12）、套细胞淋巴瘤（MCL；n = 7）和外周T细胞淋巴瘤（PTCL；n = 5）。FDG-PET在100%的LBCL和MCL患者以及98%的HL和FL患者中检测到疾病。相比之下，FDG-PET仅在67%的MZL和40%的PTCL中检测到疾病。与骨髓活检的比较表明，FDG-PET在检测任何淋巴瘤亚型的骨髓受累情况时都不可靠。
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