α-2肾上腺素能受体在前额叶皮质认知功能中的作用

[Roles of alpha-2 adrenoceptor in prefrontal cortical cognitive functions].

作者信息

Mao Z M, Li B M, Arnsten A F

机构信息

Laboratory of Neurobiology, Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai 200031.

出版信息

Sheng Li Ke Xue Jin Zhan. 1999 Jan;30(1):17-22.

PMID:12532843

Abstract

Studies in non-human primates have demonstrated that norepinephrine can improve, through actions at postsynaptical alpha-2A adrenoceptors, cognitive functions of the prefrontal cortex, such as attentional regulation, working memory and response inhibition. Several psychiatric disorders, including attention-deficit hyperactivity disorder (ADHD), show prominent syndromes seen in cognitive deficits of the prefrontal cortex. These basic studies help develop novel pharmacotherapies for psychiatric disorders such as ADHD.

摘要

对非人类灵长类动物的研究表明，去甲肾上腺素可通过作用于突触后α-2A肾上腺素能受体来改善前额叶皮质的认知功能，如注意力调节、工作记忆和反应抑制。包括注意力缺陷多动障碍（ADHD）在内的几种精神疾病，都表现出前额叶皮质认知缺陷中常见的突出症状。这些基础研究有助于开发针对ADHD等精神疾病的新型药物疗法。