无创正压通气对慢性阻塞性肺疾病合并呼吸衰竭患者气体交换及转归的影响
[Effects of noninvasive positive pressure ventilation on gas exchange and patients' transformation in chronic obstructive pulmonary disease and respiratory failure].
作者信息
Zhou R, Chen P, Luo H, Xiang X D
机构信息
Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.
出版信息
Hunan Yi Ke Da Xue Xue Bao. 2001 Jun 28;26(3):261-2.
OBJECTIVE
This paper was to observe the effects of noninvasive positive pressure ventilation (NPPV) on gas exchange and patients' transformation and to evaluate their clinical value.
METHODS
Patients were randomly treated by either NPPV, or conventional medicine. The arterial blood gas readings, heart rates (HR), and respiratory rates (HR) were obtained at admission after the treatment. It was necessary to intubate when the clinical deterioation was marked by PaCO2 > 70 mmHg, PaCO2 gradually increasing 5-10 mmHg, pH decreasing 0.05-0.1 or mental obstacle, or PaO2 < 45 mmHg.
RESULTS
NPPV significantly decreased the PaCO2 level, HR, and RR, significantly increased the PaO2 level, and also decreased the opportunity of intubation.
CONCLUSION
The results suggest that NPPV can improve the gas exchange and reduce the need of intubation in COPD patients with acute respiratory failure.
目的
本文旨在观察无创正压通气（NPPV）对气体交换及患者转归的影响，并评估其临床价值。
方法
患者被随机分为接受NPPV治疗组或传统药物治疗组。治疗后入院时获取动脉血气读数、心率（HR）和呼吸频率（RR）。当出现以下情况时需要插管：PaCO2>70 mmHg、PaCO2逐渐升高5 - 10 mmHg、pH降低0.05 - 0.1或出现精神障碍，或PaO2<45 mmHg，提示临床病情恶化。
结果
NPPV显著降低了PaCO2水平、HR和RR，显著提高了PaO2水平，且减少了插管的机会。
结论
结果表明，NPPV可改善慢性阻塞性肺疾病（COPD）急性呼吸衰竭患者的气体交换并减少插管需求。
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