利用全氟烷磺酰氟便捷合成含氟核苷。
Convenient synthesis of fluorinated nucleosides with perfluoroalkanesulfonyl fluorides.
作者信息
Takamatsu Satoshi, Katayama Satoshi, Hirose Naoko, De Cock Etienne, Schelkens Geert, Demillequand Marc, Brepoels Jozef, Izawa Kunisuke
机构信息
AminoScience Laboratories, Ajinomoto Co., Inc., 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki 210-8681, Japan.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2002 Nov-Dec;21(11-12):849-61. doi: 10.1081/NCN-120016572.
PMID:12537026
Abstract
Perfluoroalkanesulfonyl fluorides are effective dehydroxy-fluorination agents for the hydroxyl group at the sugar moiety of nucleoside derivatives and give the corresponding fluorinated nucleosides in good yield with an inversion of configuration in a single step.
摘要
全氟烷磺酰氟是核苷衍生物糖部分羟基的有效脱羟基氟化剂，能一步高产率地得到相应的氟化核苷，且构型翻转。
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