Coulthard Paul, Esposito Marco, Worthington Helen V, Jokstad Asbjorn
Oral and Maxillofacial Surgery, University Dental Hospital of Manchester, England, UK.
J Dent Educ. 2003 Jan;67(1):64-8.
The aim of this systematic review was to investigate the effectiveness of hyperbaric oxygen (HBO) therapy for irradiated patients who require dental implants using data from randomized controlled clinical trials (RCTs). The review was prepared according to Cochrane Collaboration guidelines. The Cochrane Oral Health Group Specialist Register and the Cochrane Controlled Trials Register were searched (Cochrane Library 2002, Issue 2), together with Medline from 1966 or Embase from 1974. Several journals were hand-searched, and fifty-five implant manufacturers were contacted in an attempt to identify ongoing or unpublished studies. The results were that no RCTs comparing HBO with no HBO for implant treatment in irradiated patients were identified. Our principal conclusions are that clinicians ought to be aware and make patients aware of the lack of reliable clinical evidence for or against the clinical effectiveness of HBO therapy in irradiated patients requiring dental implants. There is a need for RCTs to determine the effectiveness of HBO.
本系统评价的目的是利用随机对照临床试验（RCT）的数据，调查高压氧（HBO）疗法对需要种植牙的受辐照患者的有效性。该评价是根据Cochrane协作网指南编写的。检索了Cochrane口腔健康组专业注册库和Cochrane对照试验注册库（Cochrane图书馆2002年第2期），以及1966年以来的Medline或1974年以来的Embase。对手检了几种期刊，并联系了55家种植体制造商，试图确定正在进行或未发表的研究。结果是，未发现比较HBO与非HBO用于受辐照患者种植治疗的RCT。我们的主要结论是，临床医生应该意识到并让患者意识到，对于HBO疗法在需要种植牙的受辐照患者中的临床有效性，缺乏可靠的临床证据支持或反对。需要进行RCT来确定HBO的有效性。
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