LEW/Jms大鼠品系遗传性疾病中脑积水表达的特征

Characteristics of hydrocephalus expression in the LEW/Jms rat strain with inherited disease.

作者信息

Jones Hazel C, Carter Barbara J, Morel Laurence

机构信息

Department of Pharmacology and Therapeutics, University of Florida, P.O. Box 100267, Gainesville, FL 32610, USA.

出版信息

Childs Nerv Syst. 2003 Jan;19(1):11-8. doi: 10.1007/s00381-002-0671-3. Epub 2002 Dec 13.

DOI:10.1007/s00381-002-0671-3

PMID:12541080

Abstract

MATERIALS AND METHODS

The expression and severity of hydrocephalus was characterized in LEW/Jms rats with inherited hydrocephalus.

RESULTS

The frequency of overt disease (lethal) was 27.7%, but varied depending on breeding line. It increased to 31.5% when rats with mild disease were included. Most breeding pairs (48/51) produced hydrocephalic offspring with significantly more males than females affected. Some adult rats were also found to have mild (nonlethal) ventricular dilatation. When bred to Fisher F344 rats, 3% of the F(1) progeny had overt hydrocephalus, indicating that the trait is not recessive. Overt hydrocephalus was 9-20% in N(2) rats (F(1) rats x LEW/Jms). The frequency of hydrocephalus and the presence of an excess of hydrocephalic males, varied depending on the direction of the cross. Mild hydrocephalus in N(2) rats was 3.1%.

CONCLUSION

It is concluded that the inheritance of hydrocephalus in LEW/Jms strain is probably not mendelian recessive but may be semidominant or involve more than one gene and has a male bias indicating possible linkage to sex chromosomes.

摘要

材料与方法

在患有遗传性脑积水的LEW/Jms大鼠中对脑积水的表达和严重程度进行了表征。

结果

显性疾病（致死性）的发生率为27.7%，但因繁殖系而异。当纳入患有轻度疾病的大鼠时，该发生率增至31.5%。大多数繁殖对（48/51）产生的脑积水后代中，受影响的雄性明显多于雌性。还发现一些成年大鼠有轻度（非致死性）脑室扩张。当与Fisher F344大鼠杂交时，3%的F(1)后代有显性脑积水，表明该性状不是隐性的。N(2)大鼠（F(1)大鼠×LEW/Jms）中的显性脑积水为9 - 20%。脑积水的发生率以及脑积水雄性过多的情况因杂交方向而异。N(2)大鼠中的轻度脑积水为3.1%。