Chen Z L, Zhang L, Wang M, Huang Y
Department of Chemistry, Fuzhou University, Fuzhou 350002, China.
Se Pu. 2001 May;19(3):236-8.
An HPLC method is described for the determination of chlorpheniramine, paracetamol and pseudoephedrine hydrochloride simultaneously in Nuonuo composite tablets. Chromatographic conditions were: column, YWG-C18 column (150 mm x 4.0 mm i.d., 10 microns); mobile phase, 25% methanol(0.05 mol/L sodium dihydrogen phosphate); flow rate, 1.0 mL/min; detection wavelength, 205 nm; injection volume, 20 microL. The detection limits of chlorpheniramine, paracetamol and pseudo-ephedrine hydrochloride were 1.16 mg/L, 0.15 mg/L and 1.82 mg/L respectively and the corresponding average recoveries were 98.35% (n = 5, RSD = 1.60%), 101.16% (n = 5, RSD = 1.50%) and 98.50% (n = 5, RSD = 1.59%) respectively. The proposed method is simple, rapid and accurate and has been satisfactorily used for the quantitative analysis of real samples.
描述了一种用于同时测定诺诺复方片中氯苯那敏、对乙酰氨基酚和盐酸伪麻黄碱的高效液相色谱法。色谱条件为：色谱柱，YWG-C18柱（150 mm×4.0 mm内径，10微米）；流动相，25%甲醇（0.05 mol/L磷酸二氢钠）；流速，1.0 mL/min；检测波长，205 nm；进样体积，20微升。氯苯那敏、对乙酰氨基酚和盐酸伪麻黄碱的检测限分别为1.16 mg/L、0.15 mg/L和1.82 mg/L，相应的平均回收率分别为98.35%（n = 5，RSD = 1.60%）、101.16%（n = 5，RSD = 1.50%）和98.50%（n = 5，RSD = 1.59%）。该方法简便、快速、准确，已成功用于实际样品的定量分析。
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