Cytokines regulate c-Met expression in cultured astrocytes.
作者信息
Shimazaki Kenji, Yoshida Kazunari, Hirose Yuji, Ishimori Hisatsugu, Katayama Makoto, Kawase Takeshi
机构信息
Department of Neurosurgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
出版信息
Brain Res. 2003 Feb 7;962(1-2):105-10. doi: 10.1016/s0006-8993(02)03975-6.
We investigated c-Met expression in cultured astrocytes and their regulation by cytokines. Immunocytochemistry revealed that c-Met was expressed in cultured astrocytes. Western blotting revealed that acidic and basic fibroblast growth factor (FGF) enhanced and hepatocyte growth factor (HGF) reduced c-Met expression. Reverse transcription-polymerase chain reaction revealed that FGFs and HGF enhanced c-met expression. These findings suggest that c-Met expressed in astrocytes may have important roles during the nervous system regeneration.
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