3-乙酰氨基-1,4-二-O-乙酰基-2,3,5-三脱氧-5-C-(异丙基膦酰基)-D-赤藓糖戊吡喃糖的合成与结构分析

Synthesis and structural analyses of 3-acetamido-1,4-di-O-acetyl-2,3,5-trideoxy-5-C-(isopropylphosphinyl)-D-erythro-pentopyranoses.

作者信息

Oshikawa Tatsuo, Seo Kuniaki, Yamashita Mitsuji, Hanaya Tadashi, Hamauzu Yoshihiro, Yamamoto Hiroshi

机构信息

Department of Material Sciences and Biochemistry, Numazu College of Technology, 410-8501, Numazu, Japan.

出版信息

Carbohydr Res. 2003 Jan 31;338(3):283-91. doi: 10.1016/s0008-6215(02)00397-x.

DOI:10.1016/s0008-6215(02)00397-x

PMID:12543562

Abstract

1H NMR spectroscopy of phosphorus containing hetero sugars (phospha sugars), revealed the alpha and beta configurations and chair conformations for 3-acetamido-1,4-di-O-acetyl-2,3,5-trideoxy-5-C-(isopropylphosphinyl)-alpha- and beta-D-erythro-pentopyranoses. The conformation of the title compounds was determined by 1H NMR as 1C4 in CDCl3 and the conformation was in accord with that in solid state determined by X-ray crystallographic analysis.

摘要

含磷杂糖（磷糖）的1H核磁共振光谱揭示了3-乙酰氨基-1,4-二-O-乙酰基-2,3,5-三脱氧-5-C-（异丙基膦酰基）-α-和β-D-赤藓戊吡喃糖的α和β构型以及椅式构象。通过1H核磁共振确定标题化合物在CDCl3中的构象为1C4，且该构象与通过X射线晶体学分析确定的固态构象一致。