大鼠体内头孢曲松药代动力学的每日变化
Daily variations in ceftriaxone pharmacokinetics in rats.
作者信息
Rebuelto M, Ambros L, Rubio M
机构信息
Farmacología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, 1427 Buenos Aires, Argentina.
出版信息
Antimicrob Agents Chemother. 2003 Feb;47(2):809-12. doi: 10.1128/AAC.47.2.809-812.2003.
Abstract
The aim of this study was to determine whether the time of day ceftriaxone was administered modified its pharmacokinetics. Ceftriaxone was given intraperitoneally at either 0400, 1000, 1600, and 2200 h to Sprague-Dawley rats synchronized under a light-dark cycle of 12 h of light and 12 h of dark. Pharmacokinetic parameters were analyzed for the presence of a 24-h rhythm. Results showed significant daily variations (P < 0.05) in ceftriaxone clearance, with the highest values during the dark phase. It is concluded that time-dependent variations in ceftriaxone pharmacokinetics may affect the therapeutic efficacy of current once-daily dosing schedules.
摘要
本研究的目的是确定头孢曲松给药的时间是否会改变其药代动力学。在12小时光照和12小时黑暗的明暗周期下，于04:00、10:00、16:00和22:00将头孢曲松腹腔注射给同步化的Sprague-Dawley大鼠。分析药代动力学参数以确定是否存在24小时节律。结果显示，头孢曲松清除率存在显著的每日变化（P < 0.05），在黑暗期最高。结论是，头孢曲松药代动力学的时间依赖性变化可能会影响当前每日一次给药方案的治疗效果。
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