ARF激活因子GNOM的内体特异性定位与功能

Endosome-specific localization and function of the ARF activator GNOM.

作者信息

Bonifacino Juan S, Jackson Catherine L

机构信息

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Cell. 2003 Jan 24;112(2):141-2. doi: 10.1016/s0092-8674(03)00038-2.

DOI:10.1016/s0092-8674(03)00038-2

PMID:12553900

Abstract

ARF GTPases act at multiple steps of the secretory and vacuolar/lysosomal trafficking pathways, but little is known about the spatial regulation of ARF activation. In this issue of Cell, Geldner et al. demonstrate that the Arabidopsis ARF activator GNOM localizes to endosomes where it controls the polarized trafficking of the auxin efflux carrier PIN1 to the basal plasma membrane.

摘要

ARF GTP酶在分泌途径以及液泡/溶酶体运输途径的多个步骤中发挥作用，但对于ARF激活的空间调控却知之甚少。在本期《细胞》杂志中，盖尔德纳等人证明，拟南芥ARF激活剂GNOM定位于内涵体，在内涵体中它控制生长素输出载体PIN1向基底质膜的极性运输。