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SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.
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Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways.
J Clin Invest. 2001 Nov;108(10):1459-67. doi: 10.1172/JCI13939.
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Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase.
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Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3.
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Genes governing placental development.
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The molecular genetic basis for hypertrophic cardiomyopathy.
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gp130 plays a critical role in pressure overload-induced cardiac hypertrophy.
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The challenges of translating knockout phenotypes into gene function.
Cell. 2000 Jul 21;102(2):131-4. doi: 10.1016/s0092-8674(00)00017-9.
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Role of suppressors of cytokine signaling (Socs) in leukemia inhibitory factor (LIF) -dependent embryonic stem cell survival.
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Gigantism in mice lacking suppressor of cytokine signalling-2.
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