用于疫苗和药物的聚（DL-丙交酯-共-乙交酯）基递送系统。

Poly (DL-lactide-co-glycolide) based delivery systems for vaccines and drugs.

作者信息

Dhiman N, Dutta M, Khuller G K

机构信息

Department of Biochemistry, Postgraduate Institute of Medical Education & Research, Chandigarh 160 012, India.

出版信息

Indian J Exp Biol. 2000 Aug;38(8):746-52.

PMID:12557904

Abstract

Current vaccination and drug delivery strategies emphasize on the development of controlled release techniques for persistent and sustained effects. In the recent years, polymer based systems for the delivery of bioactive agents have gained considerable attention due to their marked adjuvanticity, established biodegradability and biocompatibility, excellent mechanical strength and controlled release profiles. This review deals with the potential applications of synthetic polymers mainly PLG polymers in delivery of vaccines and drugs.

摘要

当前的疫苗接种和药物递送策略着重于开发具有持久和持续效果的控释技术。近年来，基于聚合物的生物活性剂递送系统因其显著的佐剂性、已确立的生物可降解性和生物相容性、优异的机械强度以及控释特性而备受关注。本综述探讨了合成聚合物（主要是聚乳酸-羟基乙酸共聚物聚合物）在疫苗和药物递送中的潜在应用。