[18F]氟代脱氧葡萄糖正电子发射断层扫描（PET）在甲状腺髓样癌中的诊断及联合PET/CT扫描仪的应用改善

Diagnosis in medullary thyroid cancer with [18F]FDG-PET and improvement using a combined PET/CT scanner.

作者信息

Bockisch A, Brandt-Mainz Katja, Görges R, Müller St, Stattaus J, Antoch G

机构信息

Department of Nuclear Medicine, University of Essen, Germany.

出版信息

Acta Med Austriaca. 2003;30(1):22-5. doi: 10.1046/j.1563-2571.2003.02045.x.

DOI:10.1046/j.1563-2571.2003.02045.x

PMID:12558562

Abstract

Today, positron emission tomography (PET) investigation using fluorodeoxyglucose (FDG) is the most sensitive and specific single modality established for localizing metastases of medullary thyroid cancer (MTC). Even at calcitonin serum levels below 20 pg/ml, tumour localization may be successful in individual cases. However, especially in such early tumour stages, the morphological correlation using PET is unsatisfactory. With the newly available fixed combination of PET and computed tomography (PET/CT), this drawback can be overcome as PET/CT allows a point-by-point correlation of pathological function with morphological structure. Conventional PET alone yielded an approx 80 % sensitivity and specificity in MTC: a result that will be surpassed by the combined PET/CT scanner.

摘要

如今，使用氟脱氧葡萄糖（FDG）的正电子发射断层扫描（PET）检查是确定甲状腺髓样癌（MTC）转移灶最敏感、最具特异性的单一检查方法。即便降钙素血清水平低于20 pg/ml，个别病例的肿瘤定位仍可能成功。然而，尤其是在肿瘤早期阶段，PET的形态学相关性并不理想。有了新推出的PET与计算机断层扫描（PET/CT）的固定组合，这一缺点便可克服，因为PET/CT能够将病理功能与形态结构逐点关联起来。单纯传统PET对MTC的敏感性和特异性约为80%：这一结果将被PET/CT联合扫描仪超越。