子宫内环境、乳腺肿块与乳腺癌风险
Intrauterine environment, mammary gland mass and breast cancer risk.
作者信息
Trichopoulos Dimitrios
机构信息
Harvard School of Public Health, Boston, MA, USA.
出版信息
Breast Cancer Res. 2003;5(1):42-4. doi: 10.1186/bcr555. Epub 2002 Nov 7.
Abstract
Two intimately linked hypotheses on breast cancer etiology are described. The main postulate of the first hypothesis is that higher levels of pregnancy estrogens and other hormones favor the generation of a higher number of susceptible stem cells with compromised genomic stability. The second hypothesis postulates that the mammary gland mass, as a correlate of the number of cells susceptible to transformation, is an important determinant of breast cancer risk. A simple integrated etiological model for breast cancer is presented and it is indicated that the model accommodates most epidemiological aspects of breast cancer occurrence and natural history.
摘要
本文描述了两个关于乳腺癌病因的紧密相关假说。第一个假说的主要假设是，孕期雌激素和其他激素水平较高有利于产生更多基因组稳定性受损的易感干细胞。第二个假说假设乳腺体积与易发生转化的细胞数量相关，是乳腺癌风险的一个重要决定因素。本文提出了一个简单的乳腺癌综合病因模型，并指出该模型涵盖了乳腺癌发生和自然史的大多数流行病学方面。
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