引起血流感染的酵母分离株的抗真菌药敏模式。

Antifungal susceptibility patterns of yeast isolates causing bloodstream infections.

作者信息

Barchiesi Francesco, Caggiano Giuseppina, Maracci Monia, Arzeni Daniela, Scalise Giorgio, Montagna Maria Teresa

机构信息

Istituto di Malattie Infettive e Medicina Pubblica, Università degli Studi di Ancona, Azienda Ospedaliera Umberto I degrees, Via Conca 60020, Torrette di Ancona, Ancona, Italy.

出版信息

J Antimicrob Chemother. 2003 Feb;51(2):431-3. doi: 10.1093/jac/dkg073.

DOI:10.1093/jac/dkg073

PMID:12562717

Abstract

A broth microdilution method following the NCCLS recommendations was used for testing fluconazole, itraconazole, posaconazole, 5-fluorocytosine and amphotericin B against 83 yeast isolates causing bloodstream infections in 59 patients hospitalized between January 1998 and June 2001 at the University Hospital of Bari, Italy. Isolates belonged to four species of Candida and three other yeast genera. Of the isolates, 97%, 95% and 100% were susceptible to fluconazole, itraconazole and posaconazole, respectively. Similarly, 97% and 100% of the isolates were susceptible to 5-fluorocytosine and amphotericin B, respectively.

摘要

采用遵循美国国家临床实验室标准委员会（NCCLS）建议的肉汤微量稀释法，对氟康唑、伊曲康唑、泊沙康唑、5-氟胞嘧啶和两性霉素B进行测试，受试对象为1998年1月至2001年6月期间在意大利巴里大学医院住院的59例患者中引起血流感染的83株酵母分离株。分离株属于4种念珠菌属和其他3个酵母属。在这些分离株中，分别有97%、95%和100%对氟康唑、伊曲康唑和泊沙康唑敏感。同样，分别有97%和100%的分离株对5-氟胞嘧啶和两性霉素B敏感。