Wherry E John, Teichgräber Volker, Becker Todd C, Masopust David, Kaech Susan M, Antia Rustom, von Andrian Ulrich H, Ahmed Rafi
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Nat Immunol. 2003 Mar;4(3):225-34. doi: 10.1038/ni889. Epub 2003 Feb 3.
Memory CD8 T cells can be divided into two subsets, central (T(CM)) and effector (T(EM)), but their lineage relationships and their ability to persist and confer protective immunity are not well understood. Our results show that T(CM) have a greater capacity than T(EM) to persist in vivo and are more efficient in mediating protective immunity because of their increased proliferative potential. We also demonstrate that, following antigen clearance, T(EM) convert to T(CM) and that the duration of this differentiation is programmed within the first week after immunization. We propose that T(CM) and T(EM) do not necessarily represent distinct subsets, but are part of a continuum in a linear naive --> effector --> T(EM) --> T(CM) differentiation pathway.
记忆性CD8 T细胞可分为两个亚群，即中枢性（T(CM)）和效应性（T(EM)），但其谱系关系以及它们持续存在并赋予保护性免疫的能力尚未得到充分了解。我们的结果表明，T(CM)在体内持续存在的能力比T(EM)更强，并且由于其增殖潜力增加，在介导保护性免疫方面更有效。我们还证明，在抗原清除后，T(EM)会转化为T(CM)，并且这种分化的持续时间在免疫后的第一周内就已编程。我们提出，T(CM)和T(EM)不一定代表不同的亚群，而是线性的幼稚→效应性→T(EM)→T(CM)分化途径中连续统一体的一部分。
Nat Immunol. 2003-3
Nat Immunol. 2002-7
Proc Natl Acad Sci U S A. 2025-7-29
Oncoimmunology. 2025-12
Zotero 插件