前列腺癌侵袭性与19号染色体q臂连锁关系的确认。
Confirmation of linkage of prostate cancer aggressiveness with chromosome 19q.
作者信息
Slager S L, Schaid D J, Cunningham J M, McDonnell S K, Marks A F, Peterson B J, Hebbring S J, Anderson S, French A J, Thibodeau S N
机构信息
Department of Health Sciences Research, Mayo Clinic/Foundation, Rochester, MN 55905, USA.
出版信息
Am J Hum Genet. 2003 Mar;72(3):759-62. doi: 10.1086/368230. Epub 2003 Jan 30.
Abstract
Regions on chromosomes 7 and 19 were recently reported to contain susceptibility loci that regulate tumor aggressiveness of prostate cancer. To confirm these findings, we analyzed genome scan data from 161 pedigrees affected with prostate cancer. Using the Gleason score as a quantitative measure of tumor aggressiveness, we regressed the squared trait difference, as well as the mean-corrected cross product, on the estimated proportion of alleles shared identical-by-descent at each marker position. Our results confirm the previous linkage results for chromosome 19q (D19S902, P<.00001). In addition, we report suggestive evidence for linkage on chromosome 4 (D4S403, P=.00012). The results of previous findings, together with our results, provide strong evidence that chromosome 19 harbors a gene for tumor aggressiveness.
摘要
最近有报道称，7号和19号染色体上的区域含有调节前列腺癌肿瘤侵袭性的易感基因座。为了证实这些发现，我们分析了161个前列腺癌家系的基因组扫描数据。使用 Gleason 评分作为肿瘤侵袭性的定量指标，我们将性状差异的平方以及均值校正后的交叉乘积，对每个标记位置上等位基因通过血缘相同的估计比例进行回归分析。我们的结果证实了先前关于19号染色体q臂（D19S902，P<0.00001）的连锁结果。此外，我们报告了4号染色体上存在连锁的提示性证据（D4S403，P = 0.00012）。先前的研究结果与我们的结果共同提供了强有力的证据，表明19号染色体上存在一个与肿瘤侵袭性相关的基因。
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