Scheinman Jon I
Division of Nephrology, University of Kansas Medical Center, Kansas University Childrens Center, Kansas City, KS, USA.
Semin Nephrol. 2003 Jan;23(1):66-76. doi: 10.1053/snep.2003.50006.
Sickle cell disease (SCD) affects the kidney by acute mechanisms, as a form of the sickle crisis, and insidiously with renal medullary/papillary necrosis, with resulting tubular defects. Glomerular hyperperfusion and hypertrophy results in a chronic sickle cell nephropathy that results in a significant morbidity in the progression to end-stage kidney disease. Kidney transplantation offers a major advantage to survival, and should be coupled with efforts toward prevention of recurrent disease.
镰状细胞病（SCD）通过急性机制影响肾脏，表现为镰状细胞危象的一种形式，且会隐匿地导致肾髓质/乳头坏死，进而引起肾小管缺陷。肾小球高灌注和肥大导致慢性镰状细胞肾病，这在进展为终末期肾病的过程中会导致显著的发病率。肾移植对提高生存率具有重要优势，并且应与预防疾病复发的努力相结合。
