Metabolism of 5-(p-toluyl)-5-ethylbarbituric acid and 5-(p-toluyl)-5-phenylhydantoin in the isolated perfused rat liver.

The primary route of metabolism of 5-(p-toluyl)-5-ethylbarbituric acid (TEBA) and 5-(p-toluyl)-5-phenylhydantoin (MPPH) in the isolated perfused rat liver is oxidation of the aromatic methyl group either to a primary alcohol which is then conjugated with glucuronic acid and excreted in the bile (MPPH only) or to the carboxylic acid which is excreted free in the bile (both TEBA and MPPH). All metabolites were identified by previously described permethylation and GC-MS techniques.