环磷酰胺诱发的迟发性肺部疾病。

Cyclophosphamide-induced late-onset lung disease.

作者信息

Hamada Kunio, Nagai Sonoko, Kitaichi Masanori, Jin Guang, Shigematsu Michio, Nagao Taishi, Sato Atsuyasu, Mishima Michiaki

机构信息

Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, 53 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507.

出版信息

Intern Med. 2003 Jan;42(1):82-7. doi: 10.2169/internalmedicine.42.82.

DOI:10.2169/internalmedicine.42.82

PMID:12583625

Abstract

We report the case of a 58-year-old woman who was considered to have died of cyclophosphamide (CPA)-induced late-onset lung disease. She underwent a right-sided mastectomy due to breast cancer at the age of 50 followed by daily administration of 50 mg CPA and 20 mg tamoxifen for 2 years. A refractory cough and dyspnea began at the age of 56. Chest radiographs revealed diffuse infiltrates and pleural thickening. Her vital capacity was markedly reduced. Corticosteroid therapy was ineffective. The disease rapidly progressed with occasional episodes of pneumothoraces to her death. Postmortem examination revealed pulmonary fibrosis with marked elastosis.

摘要

我们报告了一例58岁女性病例，该患者被认为死于环磷酰胺（CPA）诱发的迟发性肺部疾病。她50岁时因乳腺癌接受了右侧乳房切除术，随后每日服用50毫克CPA和20毫克他莫昔芬，持续2年。56岁时开始出现难治性咳嗽和呼吸困难。胸部X光片显示弥漫性浸润和胸膜增厚。她的肺活量明显降低。皮质类固醇治疗无效。疾病迅速进展，偶发气胸，最终导致她死亡。尸检显示肺纤维化并伴有明显的弹性组织变性。