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入院时胎心监护:一项随机对照试验。

Admission cardiotocography: a randomised controlled trial.

作者信息

Impey Lawrence, Reynolds Margaret, MacQuillan Kathryn, Gates Simon, Murphy John, Sheil Orla

机构信息

Oxford Feto-Maternal Medicine Unit, Women's Centre, John Radcliffe Hospital, Headington, Oxford, UK.

出版信息

Lancet. 2003 Feb 8;361(9356):465-70. doi: 10.1016/S0140-6736(03)12464-6.

Abstract

BACKGROUND

Admission cardiotocography is widely used to identify pregnancies that might benefit from continuous electronic fetal monitoring in labour. We aimed to compare the effect on neonatal outcome of admission cardiotocography versus intermittent auscultation of the fetal heart rate.

METHODS

8580 women admitted to the delivery ward of a Dublin teaching hospital who were at low risk of fetal distress in labour were randomly assigned admission cardiotocography (20 min) or the unit's usual care (intermittent auscultation only, with continuous cardiotocography only if clinically indicated). The primary outcome was moderate to severe neonatal morbidity, or perinatal mortality in the absence of a major congenital malformation. Analyses were by intention to treat.

FINDINGS

44 (1.0%) women assigned admission cardiotocography did not undergo the procedure; 15 (0.4%) assigned usual care had admission cardiotocography. The primary endpoint occurred in 56 (1.3%) of 4298 women assigned admission cardiotocography and 55 (1.3%) of 4282 in the usual-care group (relative risk 1.01; 95% CI 0.70-1.47). Other indices of neonatal morbidity also showed no differences. Despite an increase in use of continuous cardiotocography (1.39; 1.33-1.45) and fetal blood sampling (1.30; 1.14-1.47) with admission cardiotocography, there were no significant differences in the rates of caesarean delivery (1.13; 0.92-1.40), instrumental delivery (1.03; 0.92-1.16), or episiotomy (1.06; 0.99-1.13).

INTERPRETATION

Routine use of cardiotocography for 20 min on admission to the delivery ward does not improve neonatal outcome. No significant increase in operative delivery was apparent, probably because of liberal use of fetal blood sampling.

摘要

背景

入院时的胎心监护被广泛用于识别那些在分娩过程中可能受益于持续电子胎儿监护的妊娠情况。我们旨在比较入院时胎心监护与间歇性听诊胎儿心率对新生儿结局的影响。

方法

8580名入住都柏林一家教学医院分娩病房、分娩时胎儿窘迫风险较低的女性被随机分配接受入院时胎心监护(20分钟)或该科室的常规护理(仅间歇性听诊,仅在临床指征明确时进行持续胎心监护)。主要结局是中度至重度新生儿发病率,或在无重大先天性畸形情况下的围产期死亡率。分析采用意向性分析。

研究结果

44名(1.0%)被分配接受入院时胎心监护的女性未进行该操作;15名(0.4%)被分配接受常规护理的女性进行了入院时胎心监护。主要终点事件在4298名被分配接受入院时胎心监护的女性中有56名(1.3%)发生,在常规护理组的4282名女性中有55名(1.3%)发生(相对风险1.01;95%置信区间0.70 - 1.47)。其他新生儿发病率指标也未显示出差异。尽管入院时胎心监护使持续胎心监护(1.39;1.33 - 1.45)和胎儿血样采集(1.30;1.14 - 1.47)的使用增加,但剖宫产率(1.13;0.92 - 1.40)、器械助产率(1.03;0.92 - 1.16)或会阴切开率(1.06;0.99 - 1.13)均无显著差异。

解读

分娩病房入院时常规进行20分钟的胎心监护并不能改善新生儿结局。手术分娩未见显著增加,可能是由于胎儿血样采集的广泛使用。

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