Hung Y C, Shiau Y C, Chang W C, Kao C H, Lin C C
Department of OBS/GYN, China Medical College Hospital, Taichung, Taiwan, ROC.
Neoplasma. 2002;49(6):415-7.
The establishment of new tumor marker combinations including strong lead-time effects in detecting recurrent cervical cancer appears to be warranted. This retrospective study includes 50 patients with recurrent squamous cell cervical cancer after operation or radiotherapy. The serial serum levels of the tumor markers tissue polypeptide specific antigen (TPS) and squamous cell carcinoma antigen (SCC) were determined. Cutoff values of 78.5 U/L for TPS and 1.5 microg/L for SCC were selected according to the 95th percentile of serum concentrations measured in healthy control patients. Comparing with other monitoring modalities, SCC and TPS showed lead-time effective in 27 and 30 cases, respectively. This difference was not statistically significant. The combination of SCC and TPS provided lead-time effects in 42 cases. Our data indicate that combination of TPS and SCC is a valuable tool in the early predicting recurrent cervical cancer.
建立新的肿瘤标志物组合以在检测复发性宫颈癌时产生显著的提前期效应似乎是有必要的。这项回顾性研究纳入了50例术后或放疗后复发性宫颈鳞状细胞癌患者。测定了肿瘤标志物组织多肽特异性抗原（TPS）和鳞状细胞癌抗原（SCC）的系列血清水平。根据健康对照患者血清浓度的第95百分位数，选择TPS的临界值为78.5 U/L，SCC的临界值为1.5 μg/L。与其他监测方式相比，SCC和TPS分别在27例和30例中显示出提前期效应。这种差异无统计学意义。SCC和TPS的联合在42例中产生了提前期效应。我们的数据表明，TPS和SCC的联合是早期预测复发性宫颈癌的有价值工具。
