Havilio Moshe, Haddad Yariv, Smilansky Zeev
Compugen Limited, 72 Pinhas Rozen Street, Tel Aviv, 69512 Israel.
Anal Chem. 2003 Feb 1;75(3):435-44. doi: 10.1021/ac0258913.
We describe a new statistical scorer for tandem mass spectrometry. The scorer is based on the probability that fragments with given chemical properties create measured intensity levels in the experimental spectrum. The scorer's parameters are computed using a fully automated procedure. Benchmarking the new scorer on a large set of experimental spectra, we show that it performs significantly better than the widely used cross-correlation scoring algorithm of Eng et al. (Eng, J. K; McKormack, A. L.; Yates, J. R. J. Am. Soc. Mass Spectrom. 1994, 5, 976-989.).
我们描述了一种用于串联质谱的新型统计评分器。该评分器基于具有给定化学性质的碎片在实验光谱中产生测量强度水平的概率。评分器的参数使用全自动程序计算。在大量实验光谱上对新评分器进行基准测试，我们表明它的性能明显优于Eng等人广泛使用的互相关评分算法（Eng, J. K; McKormack, A. L.; Yates, J. R. J. Am. Soc. Mass Spectrom. 1994, 5, 976 - 989.）。
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