Lundbäck B, Lindberg A, Lindström M, Rönmark E, Jonsson A C, Jönsson E, Larsson L G, Andersson S, Sandström T, Larsson K
Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Respir Med. 2003 Feb;97(2):115-22. doi: 10.1053/rmed.2003.1446.
The prevalence of chronic obstructive pulmonary disease (COPD) according to guidelines of today seems considerably higher than has been reported also in recent literature.
To estimate the prevalence of COPD as defined by British Thoracic Society (BTS) criteria and the recent global initiative for chronic obstructive lung disease (GOLD) criteria. Further aims were to assess the proportion of underdiagnosis and of symptoms in subjects with COPD, and to study risk factors for COPD.
In 1996, 5892 of the Obstructive Lung Disease in Northern Sweden (OLIN) Study's first cohort could be traced to a third follow-up survey, and 5189 completed responses (88%) were received corresponding to 79% of the original cohort from December 1985. Of the responders, a random sample of 1500 subjects were invited to a structured interview and a lung function test, and 1237 of the invited completed a lung function test with acceptable quality.
In ages >45 years, the prevalence of COPD according to the BTS guidelines was 8%, while it was 14% according to the GOLD criteria. The absolutely dominating risk factors were increasing age and smoking, and approximately a half of elderly smokers fulfilled the criteria for COPD according to both the BTS and the GOLD criteria. Family history of obstructive airway disease was also a risk factor, while gender was not. Of those fulfilling the BTS criteria for COPD, 94% were symptomatics, 69% had chronic productive cough, but only 31% had prior to the study been diagnosed as having either chronic bronchitis, emphysema, or COPD. The corresponding figures for COPD according GOLD were 88, 51, and 18%.
In ages >45 years, the prevalence of COPD according to the BTS guidelines was 8%, and it was 14% according to the GOLD criteria. Fifty percent of elderly smokers had developed COPD. The large majority of subjects having COPD were symptomatic, while the proportion of those diagnosed as having COPD or similar diagnoses was small.
根据当今的指南，慢性阻塞性肺疾病（COPD）的患病率似乎比近期文献报道的要高得多。
根据英国胸科学会（BTS）标准和近期慢性阻塞性肺疾病全球倡议（GOLD）标准评估COPD的患病率。进一步的目的是评估COPD患者中漏诊和有症状者的比例，并研究COPD的危险因素。
1996年，瑞典北部阻塞性肺疾病（OLIN）研究的首批队列中的5892人可追溯到第三次随访调查，共收到5189份完整回复（88%），相当于1985年12月原始队列的79%。在这些回复者中，随机抽取1500名受试者进行结构化访谈和肺功能测试，其中1237名受邀者完成了质量可接受的肺功能测试。
在年龄大于45岁的人群中，根据BTS指南，COPD的患病率为8%，而根据GOLD标准为14%。绝对占主导地位的危险因素是年龄增长和吸烟，大约一半的老年吸烟者根据BTS和GOLD标准均符合COPD标准。阻塞性气道疾病家族史也是一个危险因素，而性别不是。在符合BTS COPD标准的人群中，94%有症状，69%有慢性咳痰，但在研究前只有31%被诊断为患有慢性支气管炎、肺气肿或COPD。根据GOLD标准，COPD的相应数字分别为88%、51%和18%。
在年龄大于45岁的人群中，根据BTS指南，COPD的患病率为8%，根据GOLD标准为14%。50%的老年吸烟者患了COPD。绝大多数患有COPD的受试者有症状，而被诊断为患有COPD或类似疾病的比例较小。
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