Olave M J, Maxwell D J
Spinal Cord Group, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK.
Brain Res. 2003 Mar 7;965(1-2):269-73. doi: 10.1016/s0006-8993(02)04124-0.
In this study we used confocal microscopy to show that most (83.67%) alpha(2C)-adrenergic receptor (alpha(2C)-AR)-immunoreactive terminals in the superficial dorsal horn contain the vesicular glutamate transporter 2 and hence are glutamatergic. Few (11.33%) terminals contain glutamic acid decarboxylase (a marker for GABAergic axons) and none were associated with the B subunit of cholera toxin (a marker for myelinated primary afferents) or the vesicular glutamate transporter 1. These data indicate that most dorsal horn axons possessing the alpha(2C)-AR are excitatory and add further support to the suggestion that they originate principally from spinal interneurons.
在本研究中，我们使用共聚焦显微镜显示，在浅表背角中，大多数（83.67%）α₂C-肾上腺素能受体（α₂C-AR）免疫反应阳性终末含有囊泡谷氨酸转运体2，因此是谷氨酸能的。少数（11.33%）终末含有谷氨酸脱羧酶（γ-氨基丁酸能轴突的标志物），且没有一个与霍乱毒素B亚基（有髓初级传入纤维的标志物）或囊泡谷氨酸转运体1相关。这些数据表明，大多数具有α₂C-AR的背角轴突是兴奋性的，并进一步支持了它们主要起源于脊髓中间神经元的观点。
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