用β-淀粉样肽处理后，小鼠神经元和星形胶质细胞培养物中的乙酰胆碱酯酶增加。
Acetylcholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with beta-amyloid peptides.
作者信息
Sáez-Valero Javier, Fodero Lisa R, White Anthony R, Barrow Colin J, Small David H
机构信息
Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, 03550, San Juan de Alicante, Spain.
出版信息
Brain Res. 2003 Mar 7;965(1-2):283-6. doi: 10.1016/s0006-8993(02)04159-8.
The cellular origin of the acetylcholinesterase (AChE) associated with amyloid plaques in the Alzheimer's disease (AD) brain is unknown. In this study we report that amyloid beta-peptides (Abeta) increased AChE levels in both neuronal and astrocytic primary cultures, supporting the possibility that both neurons and glia may make a direct contribution to the pool of AChE seen around amyloid deposits in the AD brain.
与阿尔茨海默病（AD）大脑中淀粉样斑块相关的乙酰胆碱酯酶（AChE）的细胞起源尚不清楚。在本研究中，我们报告淀粉样β肽（Aβ）在神经元和星形胶质细胞原代培养物中均增加了AChE水平，这支持了神经元和神经胶质细胞可能对AD大脑中淀粉样沉积物周围所见的AChE池有直接贡献的可能性。
Zotero 插件