酿酒酵母的ldb1突变体在Pmr1p（酵母分泌途径/高尔基体Ca(2+)/Mn(2+) -ATP酶）中存在缺陷。
The ldb1 mutant of Saccharomyces cerevisiae is defective in Pmr1p, the yeast secretory pathway/Golgi Ca(2+)/Mn(2+)-ATPase.
作者信息
Olivero Isabel, Corbacho Isaac, Hernández Luis M
机构信息
Department of Microbiology. University of Extremadura, 06071, Badajoz, Spain.
出版信息
FEMS Microbiol Lett. 2003 Feb 14;219(1):137-42. doi: 10.1016/S0378-1097(03)00002-8.
The LDB1 gene of Saccharomyces cerevisiae was identified by complementation of the ldb1 mutant phenotype with a genomic library. We found that the ldb1 defect is complemented by PMR1 which codes for the yeast secretory pathway/Golgi Ca(2+)/Mn(2+)-ATPase. Besides that, the analysis of a null mutation of the PMR1 gene revealed a phenotype identical to that of ldb1 mutant. Thus, LDB1 must be considered a synonym of PMR1.
通过用基因组文库互补ldb1突变体表型，鉴定出酿酒酵母的LDB1基因。我们发现，ldb1缺陷可由编码酵母分泌途径/高尔基体Ca(2+)/Mn(2+)-ATP酶的PMR1互补。除此之外，对PMR1基因无效突变的分析揭示了与ldb1突变体相同的表型。因此，LDB1必须被视为PMR1的同义词。
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