Driul L, Furlan R, Macagno F, Pezzani I, Plaino L, Ianni A, Casarsa S, Zavarise D, Marchesoni D
Clinica di Ostetricia e Ginecologia Dipartimento di Scienze Chirurgiche Università degli Studi di Udine, Udine, Italy.
Minerva Ginecol. 2003 Feb;55(1):37-42.
The aim of this study was to evaluate the effect of antenatal maternal corticosteroid treatment on the frequency of neonatal outcomes and perinatal infectious morbidity among singleton pregnancies complicated by preterm delivery.
A nonrandomized analysis was performed on 189 neonates of 24-34 weeks' gestation who were born at the Department of Obstetrics and Gynecology, University of Udine, between January 2000 to December 2001. The neonates were subdivided into 3 groups: 1) 143 neonates received 2 doses of corticosteroids in a 24-hour interval and repeated after 10 days; 2) 26 neonates received 2 doses; 3) 20 neonates did not receive any treatment. Data were analysed with the Fisher exact test. p<0.05 was considered significant.
The incidence of respiratory distress syndrome (RDS), neonatal mortality and intraventricular hemorrhage was respectively 43.4%, 3.2 % and 6.3 %. The rate of early-onset neonatal sepsis was 4.9% in the 1st group, 3.9% in the 2nd group and 5% in the 3rd group. There were no significant differences in the early-onset neonatal sepsis and the antenatal corticosteroids treatment.
The single or the multiple courses of antenatal steroids did not apparently increase neonatal sepsis in patients with preterm delivery.
本研究旨在评估产前母体使用皮质类固醇治疗对单胎妊娠并发早产的新生儿结局频率和围产期感染性发病率的影响。
对2000年1月至2001年12月在乌迪内大学妇产科出生的189例孕24 - 34周的新生儿进行非随机分析。将新生儿分为3组：1）143例新生儿在24小时内接受2剂皮质类固醇治疗，并在10天后重复给药；2）26例新生儿接受2剂治疗；3）20例新生儿未接受任何治疗。数据采用Fisher精确检验进行分析。p<0.05被认为具有统计学意义。
呼吸窘迫综合征（RDS）、新生儿死亡率和脑室内出血的发生率分别为43.4%、3.2%和6.3%。第1组早发型新生儿败血症的发生率为4.9%，第2组为3.9%，第3组为5%。早发型新生儿败血症与产前皮质类固醇治疗之间无显著差异。
对于早产患者，单次或多次产前使用类固醇并未明显增加新生儿败血症的发生。
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