Llewellyn G C, Sherertz P C, Mills R R
Bull Environ Contam Toxicol. 1976 Apr;15(4):391-7. doi: 10.1007/BF01685060.
In general these studies seem to indicate that adult male P. americana are not particularly sensitive, toxicologically, to aflatoxin B1, even when maintained on a marginally inadequate diet containing a low level of sucrose and no protein. Also they may be capable of detecting low levels of aflatoxin B1 in their diet (12 mug/ml) and seem not to concentrate aflatoxin B1 in their bodies. Even in dietary stressed conditions adult male American cockroaches showed a very limited potential as a bioassay organism for this toxin. Actually it appears that they may be quite resistant to the toxin. Currently there is no definite answer as to the advantages or disadvantages of insufficient dietary proteins or even carbohydrates providing protection against this toxin. The results show that the toxin would not be an effective cockroach-killing agent and thus could not serve as a bioassay system. However, this insect could serve as a model system in further investigating the mode of action and possible detoxification of aflatoxin B1.
总体而言，这些研究似乎表明，从毒理学角度来看，成年雄性美洲大蠊对黄曲霉毒素B1并不特别敏感，即便饲养在蔗糖含量低且不含蛋白质的勉强维持营养的饮食中也是如此。此外，它们或许能够检测出饮食中低水平的黄曲霉毒素B1（12微克/毫升），且似乎不会在体内蓄积黄曲霉毒素B1。即便在饮食压力条件下，成年雄性美洲大蠊作为这种毒素的生物测定生物体的潜力也非常有限。实际上，它们似乎对这种毒素具有相当的抗性。目前，关于饮食中蛋白质不足甚至碳水化合物不足是否能提供针对这种毒素的保护作用，尚无明确答案。结果表明，这种毒素并非有效的蟑螂杀灭剂，因此不能用作生物测定系统。然而，这种昆虫可作为进一步研究黄曲霉毒素B1作用方式及可能的解毒机制的模型系统。
