多西他赛与卡铂联合化疗用于复发性子宫内膜癌

Docetaxel and carboplatin combination chemotherapy for recurrent endometrial cancer.

作者信息

Obata Hiroaki, Aoki Yoichi, Watanabe Minoru, Matsushita Hiroshi, Yahata Tetsuro, Fujita Kazuyuki, Kurata Hitoshi, Tanaka Kenichi

机构信息

Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi- dori, Niigata 951-8510, Japan.

出版信息

Int J Clin Oncol. 2003 Feb;8(1):53-5. doi: 10.1007/s101470300008.

DOI:10.1007/s101470300008

PMID:12601544

Abstract

There is no consensus regarding the optimal chemotherapy for endometrial cancer patients, and a need for better chemotherapy is evident. Two individuals with recurrent metastatic endometrial cancer treated with docetaxel and carboplatin combination chemotherapy are presented here. Both cases showed objective response to the chemotherapy (one complete response and the other partial response); response duration was 7 and 18 months, respectively. One patient who achieved complete response is alive without disease for 12 months after recurrence. Adverse effects in this regimen were mild and tolerable. Docetaxel in combination with carboplatin may be active agents for patients with metastatic endometrial cancer.

摘要

关于子宫内膜癌患者的最佳化疗方案尚无共识，显然需要更好的化疗方法。本文介绍了两名接受多西他赛和卡铂联合化疗的复发性转移性子宫内膜癌患者。两例患者对化疗均显示出客观反应（一例完全缓解，另一例部分缓解）；缓解持续时间分别为7个月和18个月。一名获得完全缓解的患者在复发后无病存活了12个月。该方案的不良反应轻微且可耐受。多西他赛联合卡铂可能是转移性子宫内膜癌患者的有效药物。