Thomas J M, Glynn M F, Rickwood A M, Gough M H
Br J Surg. 1976 Mar;63(3):189-95. doi: 10.1002/bjs.1800630306.
The value of anti-thrombotic drugs to maintain the patency of grafts into the central venous system is described. The infrarenal portion of the inferior vena cava in mongrel dogs was used as the test bed. Two autologous graft materials were used: first, the tissue reaction to implanted silicone rubber, and, secondly, free peritoneum. Phenylbutazone was the drug administered to inhibit the aggregation of platelets at the bloodgraft interface. The low patency rate of the control group of animals conformed with previous experimental studies. The patency of grafts in the phenylbutazone-treated animals (up to 92%) was predictable after studying the in vitro behaviour of their platelets preoperatively.
描述了抗血栓药物在维持植入中心静脉系统移植物通畅方面的价值。用杂种狗的肾下腔静脉部分作为试验平台。使用了两种自体移植物材料：第一，对植入硅橡胶的组织反应；第二，游离腹膜。使用苯基丁氮酮药物来抑制血小板在血液-移植物界面的聚集。动物对照组的低通畅率与先前的实验研究一致。在术前研究了苯基丁氮酮治疗动物血小板的体外行为后，其移植物的通畅率（高达92%）是可预测的。
