Fukui Daisuke, Chiba Shigetoshi
Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Circ J. 2003 Mar;67(3):259-62. doi: 10.1253/circj.67.259.
Establishing the existence of alpha-adrenoceptor subtypes in isolated human gastroepiploic and omental arteries was the goal of the present study. Functional vascular reactivity of selective alpha(1)- and alpha(2)-adrenoceptor agonists and antagonists was studied, using a cannula inserting technique. Intraluminal administration of norepinephrine (NE), phenylephrine (PE) or BHT-933 caused a vasoconstrictive response in a dose-related manner. The relative potencies of the 3 agonists were almost the same in both arteries. NE-induced vasoconstrictions were significantly antagonized by either prazosin or rauwolscine. PE-induced responses were strongly inhibited by prazosin. BHT-933-induced constrictions were inhibited by rauwolscine. These results indicate that both alpha(1)- and alpha(2)-adrenoceptors exist in the human gastroepiploic and omental arteries.
本研究的目的是确定在分离的人胃网膜动脉和网膜动脉中是否存在α-肾上腺素能受体亚型。采用插管技术研究了选择性α(1)-和α(2)-肾上腺素能受体激动剂和拮抗剂的功能性血管反应性。腔内注射去甲肾上腺素（NE）、苯肾上腺素（PE）或BHT-933会引起剂量相关的血管收缩反应。这三种激动剂在两条动脉中的相对效力几乎相同。NE诱导的血管收缩可被哌唑嗪或萝芙木碱显著拮抗。PE诱导的反应被哌唑嗪强烈抑制。BHT-933诱导的收缩被萝芙木碱抑制。这些结果表明，α(1)-和α(2)-肾上腺素能受体均存在于人胃网膜动脉和网膜动脉中。
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